Entertainment | box office Horton Hears a Box Office Hit $45.1M opening is year's biggest By Matt Cantor Posted Mar 16, 2008 5:35 PM CDT Copied Actress-singer Raven-Symone, left, talks with VJ Lyndsey Rodrigues during an appearance on MTV's "Total Request Live", Tuesday, March 4, 2008 in New York. (AP Photo/Evan Agostini) Dr. Seuss’ Horton Hears a Who! stomped into theaters this weekend for the year's biggest box office debut, Variety reports. Its $45.1 million draw is the fifth-highest for a G-rated animated flick ever and the fourth-biggest March opener. “It played to whos from ages 2 to 92,” said an exec at Twentieth Century Fox, which produced the film. Last week’s number one, 10,000 BC, fell to second with $16.4 million, while martial arts movie Never Back Down kicked into third with $8.61 million. Family flick College Road Trip slid from second to fourth at $7.89 million and killer thriller Vantage Point fired into fifth with $5.4 million, Bloomberg reports. Read These Next Mom allegedly passed 31 hospitals on road trip as daughter was dying. Tatiana Schlossberg says she has Terminal cancer. One of the Slender Man attackers escaped her group home, briefly. Anthem's new policy isn't going over well with hospitals. Report an error